Palladium-catalyzed oxidative arene C–H alkenylation reactions involving olefins

Palladium-catalyzed oxidative arene C–H alkenylation reactions with alkenes has increased the toolbox of synthetic for C–C bond formation to provide access biologically relevant molecules and drugs in an efficient, atom-economical, environmentally friendly way.The use easily removable or transient directing groups and/or ligands allows control site selectivity achieve selective functionalization C(sp2)–H bonds at ortho, meta, para, even remote positions, also improving reactivity.The intramolecular variant these can lead construction a variety heterocyclic systems via exo endo processes.Ligand design is key achieving enantioselective generate central, axial, planar chirality. The palladium-catalyzed reaction been established as central transformation enable carbon–carbon way. It provides powerful alternative classical cross-coupling conjugated organic molecules, including late-stage functionalization. knowledge mechanisms, different strategies selectivity, development efficient chiral catalysts have expanded application this tool synthesis complexity. Mizoroki–Heck (see Glossary) [1.Molander G.A. Science Synthesis: Cross Coupling Heck-Type Reactions. Vol. 1–3. Thieme, 2013Google Scholar] recognized fundamental due its broad applicability C(sp2)–C(sp2) bonds. However, it requires preinstallation carbon–(pseudo)halide (C–X) substrate. Consequently, Heck reaction, Fujiwara–Moritani recently gained much attention. This first described by Fujiwara Moritani late 1960s [2.Fujiwara Y. et al.Aromatic substitution olefins. VI. Arylation olefins palladium(II) acetate.J. Am. Chem. 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